Status:
COMPLETED
Genotype Guided Chemotherapy in Gastric Cancer Patients
Lead Sponsor:
Central South University
Conditions:
Metastatic Gastric Cancer
Eligibility:
All Genders
18-70 years
Phase:
PHASE2
Brief Summary
In gastric cancer patients treated with 5-FU and cisplatin, higher tumor TS levels were associated with a less favorable response (29% vs. 68%; p=0.024). Similarly, in a study in which patients were t...
Eligibility Criteria
Inclusion
- Patients must have histologically or cytologically confirmed metastatic adenocarcinoma of the stomach.
- Patients must have measurable disease, defined as at least one lesion that can be accurately measured in at least one dimension (longest diameter to be recorded) as \>20 mm with conventional techniques or as \>10 mm with spiral CT scan. See section 9.2 for the evaluation of measurable disease.
- No prior therapy for metastatic disease. Prior neo-adjuvant or adjuvant therapy is permitted if the disease free interval has been longer than 12 months.
- Age between 18 and 70 years. Because no dosing or adverse event data are currently available on the use of these regimens in patients \<18 years of age, children are excluded from this study.
- Life expectancy of greater than 3 months.
- ECOG performance status \< 2 (Karnofsky \>60%; see Appendix A).
- Patients must have normal organ and marrow function as defined below:
- Leukocytes \>3,000/microliter
- Absolute neutrophil count \>1,500/microliter
- Platelets \>100,000/microliter
- Total bilirubin \< 1.5 x ULN
- AST(SGOT)/ALT(SGPT) \<2.5 x ULN if not liver metastases \< 5 x ULN if known liver metastases
- Creatinine clearance \<1.5 x ULN
- Not pregnant. Not breast feeding. If the patient or partner is of childbearing potential, the couple will use adequate birth control in accordance with local IRB policies:
- For woman of childbearing potential:
- Patient must have negative blood pregnancy test. If sexually active, woman must either be post-menopausal (over age 50 and have not had a menstrual period for one year or more, or blood FSH level in the post-menopausal range) OR agree to use appropriate contraceptive measures for the duration of the study and for 21 days after stopping study treatment. The only birth control methods for women that are acceptable for this study are: (1) surgical sterilization (previous removal of the uterus or both ovaries or a tubal ligation) OR (2) an intrauterine device (IUD), (3) double barrier methods, (4) oral contraceptives.
- For men:
- Medically acceptable contraceptives include: (1) surgical sterilization, or (2) a condom used with a spermicide. If the female partner becomes pregnant while patient is on treatment or within 21 days after stopping treatment, the study physician must be informed.
- Ability to understand and the willingness to sign a written informed consent document.
Exclusion
- Patients may not be receiving any other chemotherapy agents.
- Patients with known active brain metastases. Patients with treated brain metastases are permitted if stable off steroids for at least 30 days. A screening head CT/MRI is not required in asymptomatic patients for this protocol.
- History of allergic reactions to 5-FU, oxaliplatin, docetaxel, or cisplatin.
- Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, or psychiatric illness/social situations that would limit compliance with study requirements.
- Patients with immune deficiency are at increased risk of lethal infections when treated with marrow-suppressive therapy. Therefore, HIV-positive patients receiving combination anti-retroviral therapy are excluded from the study because of possible pharmacokinetic interactions with the chemotherapies.
Key Trial Info
Start Date :
April 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2016
Estimated Enrollment :
330 Patients enrolled
Trial Details
Trial ID
NCT02204306
Start Date
April 1 2014
End Date
December 1 2016
Last Update
November 18 2019
Active Locations (1)
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1
Institute of Clinical Pharmacology
Changsha, Hunan, China, 410005