Status:
COMPLETED
Is Obstructive Sleep Apnoea a Risk Factor for Thoracic Aortic Aneurysm Expansion? A Prospective Cohort Study.
Lead Sponsor:
University of Zurich
Conditions:
Aortic Aneurysm
Obstructive Sleep Apnea
Eligibility:
All Genders
18-90 years
Brief Summary
The objective of this prospective cohort study in patients with a known thoracic aortic aneurysm is to test the hypothesis that yearly aneurysm progression rate is higher in patients with obstructive ...
Detailed Description
Thoracic aortic aneurysm An aortic aneurysm is defined as a localised dilatation of the aorta, which includes all three layers of the vessel, intima, media and adventitia. The incidence of thoracic ao...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Diagnosis of thoracic aortic aneurysm defined by the following parameters
- Women: at the level of the sinus of valsalva \>39mm, or ascending aorta \>42mm.
- Men: at the level of the sinus of valsalva \>44mm, or ascending aorta \>46mm.
- Age \> 18 years.
- Exclusion Criteria:
- Patients on continuous positive airway pressure (CPAP) therapy for OSA at baseline.
- Patients with known central sleep apnoea.
- Patients on morphine or other opioid medication, heroin addiction, alcohol addiction.
- Patients with moderate or severe aortic regurgitation.
- Patients with moderate or severe aortic stenosis.
- Pregnant patients.
Exclusion
Key Trial Info
Start Date :
July 5 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 1 2020
Estimated Enrollment :
230 Patients enrolled
Trial Details
Trial ID
NCT02204774
Start Date
July 5 2014
End Date
March 1 2020
Last Update
March 4 2020
Active Locations (1)
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1
University Hospital Zurich, Pneumology
Zurich, Switzerland, 8091