Status:
COMPLETED
To Define the Role of GLP-1 for Improving Glucose Homeostasis in Humans Following Gastric Bypass Surgery
Lead Sponsor:
Washington University School of Medicine
Collaborating Sponsors:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions:
Bypass, Gastric
Roux-en-Y Gastric Bypass
Eligibility:
All Genders
18-65 years
Phase:
PHASE1
Brief Summary
There is a marked and long-lasting improvement in glucose homeostasis that follows Roux-en-y gastric bypass surgery (RYGB) in humans. This improvement has been attributed in large part to an intestina...
Detailed Description
To conduct this study, we will enroll humans who previously underwent Roux-en-Y gastric bypass surgery, who are medically and weight stable and with no signs of type 2 diabetes either before or after ...
Eligibility Criteria
Inclusion
- Individuals must be able to consent for their own participation (no mental impairment affecting cognition or willingness to follow study instructions).
- Healthy, weight stable, with previous Roux-en-Y gastric bypass surgery and no clinical evidence of type 2 diabetes either before and after Roux-en-Y gastric bypass surgery.
- Women of childbearing potential must be currently taking/using a method of birth control that is acceptable to the investigators. A pregnancy test will be done at the beginning of each visit. Any woman with a positive pregnancy test will be removed from the study.
- Willingness to return have 8-10ml of blood drawn 25-30 days after the last Xenin infusion; to check for Xenin peptide antibodies that MAY develop. (All efforts will be made to complete this visit during study participation.)
Exclusion
- Lacks cognitive ability to sign the consent \&/or follow the study directions for themselves.
- Women unwilling to comply with using an acceptable method of contraception during the course of the study, or who are currently breast-feeding.
- Volunteers with a history of Acute Pancreatitis.
- Volunteers with a history of cancer (except for skin cancer).
- Volunteer with a history of Chronic Pancreatitis and/or risk factors for chronic pancreatitis including hypertriglyceridemia (triglycerides \>400mg/ml) hypercalcemia (blood calcium level \>11.md/dl) and/or the presence of gallstones.
- Subjects taking medications known to affect glucose tolerance.
- Hematocrit from the lab is below 33% (or if the finger stick hemoglobin measured with the HemoCue 201+ is \<11.2 g/dl).
- Any major medical conditions, or conditions that in the opinion of the PI make the subject unsuitable for the study.
- Subjects with abnormal kidney function as measured by the Creatinine concentration will be excluded.
- Subjects with a history of active liver disease or AST/ALT levels \>2X upper limit of normal will also be excluded.
- Total Bilirubin levels should be \<2.
- Subjects unwilling to allow the use of their own blood or albumin in the preparation of the peptides. (The blood will prevent sticking of the peptide to the tubing; an alternative method has been sought but not found.)
- Unwillingness to return have 8-10ml of blood drawn 25-30 days after the last Xenin infusion; to check for Xenin peptide antibodies that MAY develop. (All efforts will be made to complete this visit during study participation.)
Key Trial Info
Start Date :
July 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 17 2015
Estimated Enrollment :
13 Patients enrolled
Trial Details
Trial ID
NCT02204813
Start Date
July 1 2014
End Date
November 17 2015
Last Update
April 27 2018
Active Locations (1)
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1
Washington University School of Medicine
St Louis, Missouri, United States, 63110