Status:
COMPLETED
Effects of Korean Red Ginseng on Semen Parameters in Male Infertility Patients: a Randomized, Placebo-controlled, Double-blind Clinical Study
Lead Sponsor:
Pusan National University Hospital
Conditions:
Male Infertility
Eligibility:
MALE
25-45 years
Phase:
PHASE4
Brief Summary
Korean Red ginseng (KRG) has long been applied to various diseases as a health-promoting herbal medicine in Korea. Many clinical studies of ginseng have been performed to elucidate its therapeutic cha...
Eligibility Criteria
Inclusion
- Patients should be males, 25 - 45 years of age, who had complained of infertility for at least 12 months, and had no history of surgical or medical treatments for infertility.
- Increased retrograde flow in the internal spermatic vein with venous diameter \> 3 mm during the Valsalva maneuver on scrotal ultrasonography was used as an indicator of varicocele \[13\].
- Varicocele was graded according to the criteria presented by Lyon et al. \[14\]: \*Grade I, palpable only with the Valsalva maneuver
- Grade II, palpable without the Valsalva maneuver
- Grade III, visible from a distance.
Exclusion
- A history of vasectomy or obstructive azoospermia
- Chromosomal abnormalities
- Hypogonadism or pituitary abnormalities
- Anatomical abnormality of the genitals
- Significant hepatopathy (liver enzymes elevated 2 - 3-fold higher than the normal range)
- Renal insufficiency (serum creatinine level \> 2.5 mg/dL)
- Medical treatment for infertility during the past 4 weeks.
Key Trial Info
Start Date :
April 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2013
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT02204826
Start Date
April 1 2011
End Date
December 1 2013
Last Update
August 29 2018
Active Locations (1)
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1
Department of Urology, Pusan National University Hospital
Busan, South Korea, 602-739