Status:
COMPLETED
Cognition And Neocortical Volume After Stroke
Lead Sponsor:
The Florey Institute of Neuroscience and Mental Health
Collaborating Sponsors:
National Health and Medical Research Council, Australia
Conditions:
Ischaemic Stroke
Alzheimer's Disease
Eligibility:
All Genders
18+ years
Brief Summary
Stroke and dementia are two of the most common and disabling conditions worldwide, responsible for an enormous and growing burden of disease. There is increasing awareness that the two conditions are ...
Detailed Description
Our primary outcome measure was total brain volume (TBV) change between the 3-month and 3-year time-points compared between stroke patients and controls. Secondary outcome 1 was TBV change between 3-...
Eligibility Criteria
Inclusion
- Clinical stroke
- Aged greater than 18 years;
- Able to have cognitive testing and MRI scan; and
- Able to give informed consent
Exclusion
- Significant medical comorbidities precluding participation in cognitive testing, or making survival for three years unlikely;
- Normal exclusion criteria for MRI; e.g., implanted metal, severe claustrophobia;
- Pre-existing dementia
- Pregnancy, as a precaution to prevent exposing them to multiple MRI scans in a 12-month period
- People in existing dependent or unequal relationships with any member of the research team, to protect against coercion
Key Trial Info
Start Date :
May 1 2011
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 30 2021
Estimated Enrollment :
175 Patients enrolled
Trial Details
Trial ID
NCT02205424
Start Date
May 1 2011
End Date
June 30 2021
Last Update
June 10 2022
Active Locations (3)
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1
Eastern Health
Box Hill, Victoria, Australia, 3128
2
Austin Health
Heidelberg, Victoria, Australia, 3084
3
Melbourne Health
Parkville, Victoria, Australia, 3050