Status:
COMPLETED
The Effects of Hydromorphone on Responses to Verbal Tasks
Lead Sponsor:
University of Chicago
Collaborating Sponsors:
National Institute on Drug Abuse (NIDA)
Conditions:
Healthy
Eligibility:
All Genders
18-40 years
Phase:
NA
Brief Summary
In this study, the investigators will examine the effects of hydromorphone, as compared to placebo, upon physiological, subjective, and hormonal responses to a stressful speech task and a non-stressfu...
Detailed Description
Participants be randomly assigned to receive 1000 mg acetaminophen, 2mg hydromorphone, 4mg hydromorphone, or placebo at each of two sessions; one during which they well participate in a stressful spea...
Eligibility Criteria
Inclusion
- Healthy adult volunteers
Exclusion
- any current medical condition requiring medication or abnormal electrocardiogram
- current or past medical condition considered to be a contraindication for the study conditions
- any current Axis I psychiatric disorder (APA, 1994) including Substance Use Disorder, or Anxiety Disorder or Major Depression in the past year, any history of psychosis
- less than high school education
- lack of fluency in English
- night shift work
- Pregnancy, lactation or plans to become pregnant.
- Use of hormonal contraception.
- Daily cigarette smokers i.e., \>7 cigarettes per week
Key Trial Info
Start Date :
January 1 2015
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2016
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT02205983
Start Date
January 1 2015
End Date
September 1 2016
Last Update
October 9 2018
Active Locations (1)
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1
University of Chicago Hospital
Chicago, Illinois, United States, 60637