Status:
COMPLETED
Weight Loss and Obstructive Sleep Apnea
Lead Sponsor:
Rio de Janeiro State University
Conditions:
Obstructive Sleep Apnea
Eligibility:
All Genders
20-55 years
Phase:
NA
Brief Summary
The purpose of this study is to evaluate the effects of moderate energy restriction on the body adiposity, severity of OSA, blood pressure, sympathetic activity, oxidative stress, inflammatory biomark...
Detailed Description
Introduction: Nutritional intervention for weight loss is one of the treatment options for obstructive sleep apnea (OSA) in patients with excess body adiposity. However, the effects of moderate energy...
Eligibility Criteria
Inclusion
- age between 20-55 years
- body mass index (BMI) ≥ 30 kg/m2 and \< 40 kg/m2
Exclusion
- smoking
- Use of dietary supplements
- Use of medications that could interfere in body weight, metabolic profile and blood pressure
- Use of permanent pacemaker; use of α-adrenergic blocking agents
- Recent changes (within previous 6 months) in body weight (\> 3 kg), in dietary intake and in intensity or frequency of physical exercise
- Diagnosis of diabetes mellitus, hypertension, dyslipidemia (with drug treatment) and kidney disease
- Clinical history of thyroid dysfunction, angina pectoris, peripheral vascular disease, peripheral neuropathy, heart failure, liver failure, chronic pulmonary disease, gastroesophageal reflux disease, myocardial infarction and stroke; finger deformity that prevents the proper use of the sensors that are necessary to evaluate OSA and endothelial function; and previous bilateral cervical-thoracic sympathectomy
- Pregnant or lactating women were not allowed into the study
Key Trial Info
Start Date :
March 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2013
Estimated Enrollment :
21 Patients enrolled
Trial Details
Trial ID
NCT02206126
Start Date
March 1 2012
End Date
October 1 2013
Last Update
August 1 2014
Active Locations (1)
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1
Discipline of Clinical and Experimental Pathophysiology, CLINEX
Rio de Janeiro, Rio de Janeiro, Brazil, 20.551-030