Status:
ACTIVE_NOT_RECRUITING
Pancreatic Cancer Early Detection Program
Lead Sponsor:
White Plains Hospital
Conditions:
Pancreatic Cancer
Pancreas Cancer
Eligibility:
All Genders
18+ years
Brief Summary
Early detection testing is recommended for individuals at elevated risk for the development of Pancreatic Cancer. This Protocol will define sufficiently elevated risk as either equal to or greater tha...
Detailed Description
Interested individuals can be referred by physicians, or by family or friends. Individuals are informed that the purpose of this study is to collect outcome data following early detection testing bas...
Eligibility Criteria
Inclusion
- Any of the following:
- Known carrier of either the BRCA2 or CDKN2A mutation;
- Known carrier of any of the following mutations (BRCA1, MLH1, MSH2, PMS2, MSH6, EPCAM , P53, PALB2, APC, or ATM) PLUS first or second degree relative affected with pancreatic cancer;
- Individual with Peutz-Jeghers Syndrome;
- Familial Pancreatic Cancer, defined as at least two affected relatives with Pancreatic Cancer, who are first degree relatives with each other, and at least one of those affected must be first degree relative to the study subject;
- Both parents affected, any age:
- Any first degree relative diagnosed with pancreatic cancer under age 50;
- Chronic Pancreatitis Syndrome, defined by either PRSS1 or SPINK1 mutations AND appropriate clinical and family history
Exclusion
- Any medical condition that contraindicates endoscopy or biopsy
- Any medical condition that contraindicates MRI
- Status post partial or complete resection of the pancreas
- History of pancreatic cancer, either endocrine or exocrine
- Clinical suspicion of pancreatic cancer, or any previous radiographic or histologic diagnosis of a pre-malignant finding, including IPMN (Intraductal papillary mucinous neoplasm) and PanIN (Pancreatic intraepithelial Neoplasm).
- diagnosis of dementia
- Uncontrolled, current illness
- Renal insufficiency with serum creatinine greater than 2.0 mg/dl
Key Trial Info
Start Date :
April 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 1 2024
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT02206360
Start Date
April 1 2014
End Date
June 1 2024
Last Update
May 24 2024
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
White Plains Hospital
White Plains, New York, United States, 10601