Status:
RECRUITING
Prospective Evaluation of MyocaRdial PerFUSion ComputEd Tomography Trial
Lead Sponsor:
Young-Hak Kim, MD, PhD
Conditions:
Coronary Disease
Eligibility:
All Genders
20+ years
Phase:
NA
Brief Summary
The purpose of this study is to evaluate safety and effectiveness of CTP(computed tomography perfusion) guided revascularization vs FFR(Fractional flow reserve) guided revascularization
Eligibility Criteria
Inclusion
- Age 20 and more
- Diagnosed angina or angina equivalent symptom or positive exercise treadmill test
- Patients with intermediate- or high-risk probability of CAD defined by Diamond and Forester
- 70 % stenosis or more in coronary CTA
- Willing to provide informed, written consent
Exclusion
- Requirement for surgical procedure
- Cardiogenic shock and/or need for mechanical/pharmacologic hemodynamic support
- Recent STEMI (\<5 days)
- Non STEMI, if the cardiac troponin is not stable or starting to decline
- Left ventricular ejection fraction \<30%
- Life expectancy \<2 years
- Impaired renal function with an effective glomerular filtration rate less than 30mL/min/1.73 ㎡ or creatinine more than 2.0 mg/dL
- Undergoing evaluation for organ transplantation
- Participation or planned participation in another cardiovascular clinical trial
- Pregnancy
- Inability to take dual antiplatelet therapy for six months
- Previous CABG
- Left main disease requiring revascularization
- Any target lesion with in-stent restenosis
- NYHA class 3 or 4a
- Severe and persistent angina with severe limitation in everyday living activities (Canadian Cardiovascular Society grading Class IV)
Key Trial Info
Start Date :
August 12 2014
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 5 2028
Estimated Enrollment :
1000 Patients enrolled
Trial Details
Trial ID
NCT02208388
Start Date
August 12 2014
End Date
March 5 2028
Last Update
April 5 2023
Active Locations (7)
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1
Asan Medical Center
Seoul, Songpa-Gu, South Korea
2
Hallym University Sacred Heart Hospital
Anyang, South Korea
3
Gangwon National Univ. Hospital
Chuncheon, South Korea
4
Keimyung University Dongsan Medical Center
Daegu, South Korea