Status:
ACTIVE_NOT_RECRUITING
Donor Cytomegalovirus-Specific Cytotoxic T-Lymphocytes in Treating Patients With a Persistent Cytomegalovirus Infection
Lead Sponsor:
M.D. Anderson Cancer Center
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Cytomegaloviral Infection
Hematopoietic and Lymphoid Cell Neoplasm
Eligibility:
All Genders
Phase:
PHASE2
Brief Summary
This phase II trial studies how well donor cytomegalovirus-specific cytotoxic T-lymphocytes work in treating patients with a cytomegalovirus infection that has come back or has not gotten better despi...
Detailed Description
PRIMARY OBJECTIVE: I. To assess the efficacy, feasibility and safety of administering most closely human leukocyte antigen (HLA)-matched cytomegalovirus (CMV) specific cytotoxic T-lymphocytes (HMC-CT...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Patients with or without a malignancy; and/or any type of autologous or allogeneic HSCT; and/or patients who are immunocompromised with CMV infection will be included.
- Persistent CMV infection despite optimum anti-viral therapy
- Patients with CMV disease: defined as the demonstration of CMV by biopsy specimen from visceral sites (by culture or histology) or the detection of CMV by culture or direct fluorescent antibody stain in bronchoalveolar lavage fluid in the presence of new or changing pulmonary infiltrates OR
- Failure of antiviral therapy: defined as the continued presence of DNAemia (defined as \>/= 137 copies/ml by PCR) for at least 2 weeks of CMV antiviral therapy OR
- Optimum therapy is defined as at least 14 days of therapy with Ganciclovir, Foscarnet, Cidofovir, or Valganciclovir for patients with disease or CMV viremia.
- Relapse while on CMV antiviral therapy defined as recurrence of DNAemia while being on at least 2 weeks of antiviral therapy OR
- Patients who cannot tolerate standard anti-viral therapy and cannot continue anti-viral treatment due to side effect profile will be eligible independent of anti-viral therapy duration.
- Clinical status at enrollment to allow tapering of steroids equal to or less than 0.5 mg/kg/day of prednisone.
- Patients with chronic GVHD if on prednisone equal to or less than 0.5 mg/kg and not receiving second-line GVHD treatments like Pentostatin, Infliximab, Etanercept, etc.
- Written informed consent and/or signed assent line from patient, parent or guardian.
- Written informed consent from patient or legally authorized representative (LAR). Patients with cognitive impairment are eligible.
- Negative pregnancy test in female patients of childbearing potential.
- Patients ≥ 2 years.
- English and non-English speaking patients are eligible.
- Patients enrolled on this study may be enrolled on other IND studies at the discretion of the PI.
- Exclusion criteria:
- Patients receiving prednisone \>0.5 mg/kg/day at time of enrollment, or have received ATG, donor lymphocyte infusion (DLI) or Campath within 28 days of enrollment.
- Patients with other uncontrolled infections. For bacterial infections, patients must be receiving definitive therapy and have no signs of progressing infection for 72 hours prior to enrollment. For fungal infections patients must be receiving definitive systemic anti-fungal therapy and have no signs of progressing infection for 1 week prior to enrollment. Progressing infection is defined as hemodynamic instability attributable to sepsis or new symptoms, worsening physical signs or radiographic findings attributable to infection. Persisting fever without other signs or symptoms will not be interpreted as progressing infection. Patients with ongoing viral infections are excluded.
- Patients with active acute GVHD grades II-IV.
Exclusion
Key Trial Info
Start Date :
February 19 2015
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 31 2027
Estimated Enrollment :
49 Patients enrolled
Trial Details
Trial ID
NCT02210078
Start Date
February 19 2015
End Date
August 31 2027
Last Update
October 7 2025
Active Locations (1)
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1
M D Anderson Cancer Center
Houston, Texas, United States, 77030