Status:
COMPLETED
Study of Depressive Symptoms Predicting Postoperative Cognitive Dysfunction
Lead Sponsor:
Universitätsklinikum Hamburg-Eppendorf
Conditions:
Postoperative Cognitive Dysfunction
Postoperative Delirium
Eligibility:
All Genders
60+ years
Brief Summary
Postoperative cognitive dysfunction (POCD) describes a condition where cognitive functions such as attention, perception, concentration, learning, abstract thinking and problem solving are impaired po...
Detailed Description
The aetiology of POCD is multifactorial. One described risk factor is preoperative existing depressive symptoms in patients undergoing cardiac surgery. A total of 300 consecutive patients and 80 heal...
Eligibility Criteria
Inclusion
- Inclusion Criteria for patients and healthy controls:
- Age \> 60 years
- Written informed patient's consent
- Additional Inclusion Criteria for patients:
- Elective non-cardiac surgery and non-neurosurgical procedures in general anaesthesia or combined general/regional anaesthesia
- Minimum of duration of operation 120 minutes
- Baseline testing 3-14 days preoperatively
- Additional Inclusion Criteria for healthy controls:
- matched for age, gender and education
- no surgery over the study period
- Exclusion Criteria for patients and healthy control:
- German not mother tongue
- Illiteracy
- Mental disability
- Vision impairment not correctable
- Hearing impairment not correctable
- Illegal substance abuse (current or past history)
- Alcohol abuse (current or past history)
- Chronic benzodiazepine use
- Psychosis (current or past history)
- Parkinson Disease
- Dementia
- Multiple sclerosis
- Epilepsy (current or past history)
- Cerebral tumor (current or past history)
- Apoplexy or intracranial bleeding (current or past history)
- Severe traumatic brain injury (current or past history)
- Severe liver disease (Child Pugh B, C, liver insufficiency)
- Severe kidney disease with dialysis
- Mini Mental Status Examination \< 24 points
Exclusion
Key Trial Info
Start Date :
May 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 1 2018
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT02210312
Start Date
May 1 2014
End Date
October 1 2018
Last Update
April 30 2019
Active Locations (1)
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1
Department of Anaesthesiology and Intensive Care Medicine, University Hospital Hamburg Eppendorf, Univ.-Prof. Dr. med. Alwin E. Goetz and Prof. Dr. med. Christian Zoellner
Hamburg, Germany, 20246