Status:
COMPLETED
Does the Insula Control Smoking-Induced Dopamine Release? A TMS/[11C]-PHNO Study in Humans.
Lead Sponsor:
Centre for Addiction and Mental Health
Collaborating Sponsors:
Brainsway
Conditions:
Healthy
Eligibility:
All Genders
19-45 years
Phase:
NA
Brief Summary
Findings from this study may demonstrate how the insula contributes to reward pathways involved in addiction. There are three main hypotheses for this trial. The first is that inhibiting the insula us...
Detailed Description
This project will take advantage of the recently developed Deep rTMS coil to target the insular cortex. Few studies have examined the possibility of using repetitive Transcranial Magnetic Stimulation ...
Eligibility Criteria
Inclusion
- Healthy male or female
- Between the ages of 19 and 45
Exclusion
- Pregnancy.
- Presence of metal objects in the body or implanted electronic devices, that preclude safe MR scanning.
- Claustrophobia.
- Cardiovascular or cerebrovascular diseases.
- Major psychiatric disorders including mood, anxiety or psychotic disorders.
- History of or current neurological illnesses including seizure disorders, migraine, multiple sclerosis, movement disorders, head trauma, CVA or CNS tumor.
- Gross structural brain abnormalities as revealed by T1 weighted images.
- Current use or use during the previous month of medication that may affect the CNS (e.g. neuroleptics, bupropion).
- Learning disability, amnesia or other conditions that impede memory and attention.
Key Trial Info
Start Date :
July 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2015
Estimated Enrollment :
8 Patients enrolled
Trial Details
Trial ID
NCT02212405
Start Date
July 1 2014
End Date
December 1 2015
Last Update
September 1 2016
Active Locations (1)
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1
Centre for Addiction and Mental Health
Toronto, Ontario, Canada, M5S 2S1