Status:
UNKNOWN
Genetic and Environmental Risk Factors of Type 1 Autoimmune Diabetes and Its Early Complications
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Collaborating Sponsors:
Centre National de Génotypage
Institut National de la Santé Et de la Recherche Médicale, France
Conditions:
Diabetes Mellitus
Insulin-Dependent
Eligibility:
All Genders
6+ years
Brief Summary
The aim of this study is to complete the identification of genetic factors (G) and to undertake the search of environmental factors (E) predisposing to type 1 diabetes (T1D) by constituting a cohort o...
Detailed Description
Still recognized in youth only at a stage of complete beta-cell mass destruction and insulin deficiency, autoimmune T1D remains a source of major morbidity through daily life and chronic angiopathic c...
Eligibility Criteria
Inclusion
- Insulin-dependent diabetes
- Patients older than 6 months at inclusion
- European or North African geographical origin (defined by the birthplaces of the 4 grandparents), for the purpose of genetic homogeneity of the cohort
- Anti-GAD, IA2, and insulin autoantibodies, that are present only in the first year of the disease evolution, are not a criterion of absolute inclusion (low risk of error) but will be noted if they were searched at diagnosis
- Informed consent dated and voluntarily signed (patient and/or parents)
Exclusion
- Non-insulin dependent diabetes
- MODY
- Severe psychological problems, co-morbidities that could possibly invalidate informed consent
Key Trial Info
Start Date :
November 1 2004
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 1 2018
Estimated Enrollment :
20000 Patients enrolled
Trial Details
Trial ID
NCT02212522
Start Date
November 1 2004
End Date
June 1 2018
Last Update
June 28 2016
Active Locations (1)
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1
Inserm U986
Le Kremlin-Bicêtre, France, 94276