Status:
COMPLETED
Repeated-Dose Oral N-acetylcysteine for the Treatment of Parkinson's Disease
Lead Sponsor:
University of Minnesota
Collaborating Sponsors:
Parkinson's Disease Society of the United Kingdom
Conditions:
Parkinson Disease
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
The investigators are interested in evaluating the use of oral N-acetylcysteine (NAC) as therapy for Parkinson's Disease (PD) and measuring changes in brain and blood chemistry.
Detailed Description
The investigators are interested in evaluating the use of oral N-acetylcysteine (NAC) as therapy for Parkinson's Disease (PD) and measuring changes in brain and blood chemistry. The investigators' hyp...
Eligibility Criteria
Inclusion
- All participants must be 18 years or older
- All enrollees must understand and cooperate with requirements of the study in the opinion of the investigators and must be able to provide written informed consent
- Individuals with medically stable Parkinson's disease (in the opinion of the investigator)
- All participants must not have taken antioxidants NAC, glutathione, coenzyme Q-10, vitamin C, or vitamin E for 3 weeks prior to the study
- Absence of dementia in all subjects
Exclusion
- Inability to undergo MRI scanning without sedation and other MRI counterindications, such as metal in the body (see section 7.3)
- Medically unstable conditions as determined by the investigators
- Pregnant or lactating or those women of child-bearing age that are not using acceptable forms of contraception
- Diagnosis of asthma that is presently being treated with any medication, or past history of asthma/bronchospasm resulting in an emergency room visit, hospitalization or treatment
- Unable to adhere to study protocol for whatever reason
Key Trial Info
Start Date :
September 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2015
Estimated Enrollment :
8 Patients enrolled
Trial Details
Trial ID
NCT02212678
Start Date
September 1 2014
End Date
September 1 2015
Last Update
May 16 2019
Active Locations (1)
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1
University of Minnesota
Minneapolis, Minnesota, United States, 55455