Status:
COMPLETED
Differentiation of Pseudoprogression and True Progression Through High Field Susceptibility Weighted Imaging and R2*
Lead Sponsor:
Centre for Functional and Metabolic Mapping
Collaborating Sponsors:
London Regional Cancer Program, Canada
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Conditions:
Radiation Injury
Radiation Necrosis
Eligibility:
All Genders
18+ years
Brief Summary
Using a multi-echo gradient echo sequence to calculate R2\* and quantitative susceptibility maps and well as susceptibility-weighted imaging post processing the investigators hypothesize that the inve...
Detailed Description
Post-treatment radiographic imaging change (PTRIC) is seen in approximately 50% of patients who are treated for brain neoplasms using chemotherapy and radiotherapy. PTRIC can be attributed to true dis...
Eligibility Criteria
Inclusion
- The subject must consent to participate.
- The subject must be above the age of 18.
- Patients must be classified as possible pseudoprogression or true progression
- Patients scoring \>= 70 on the karnofsky performance status.
Exclusion
- Any subject with contraindication to an MRI procedure as listed in the Magnetic Resonance Environment Screening Questionnaire.
- Any subject who may be unable to tolerate the MRI environment due to physical size and/or known tendency to claustrophobia.
- Any subject who does not expect to be available to attend the for the required study MRI scans
- Patients scoring \< 70 on the karnofsky performance status.
- Attending radiation oncologist or neurologist determines patient is no longer able to consent for themselves.
Key Trial Info
Start Date :
July 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 1 2016
Estimated Enrollment :
18 Patients enrolled
Trial Details
Trial ID
NCT02212964
Start Date
July 1 2014
End Date
March 1 2016
Last Update
March 31 2016
Active Locations (1)
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1
University of Western Ontario
London, Ontario, Canada, N6G2J9