Status:
COMPLETED
Micro RNAs as a Marker of Aortic Aneurysm in Hereditary Aortopathy Syndromes
Lead Sponsor:
University of Colorado, Denver
Conditions:
Marfan Syndrome
Loeys-Dietz Syndrome
Eligibility:
All Genders
30-60 years
Brief Summary
The primary objective of this study is to determine whether specific patterns of circulating micro-ribonucleic acids (miRNAs) are associated with aortic aneurysm and dissection in patients with heredi...
Eligibility Criteria
Inclusion
- To be in the study, the participant must meet the following criteria
- Diagnosis of hereditary aortopathy based upon:
- Confirmation of a disease causing mutation in a known aortopathy disorder OR
- Confirmation of disease based on published clinical criteria
- Participants is male or female and greater than 30 days old
- Participants are able to undergo standard of care cardiac monitoring including an echocardiogram
- Willing and able to provide written informed consent by parent(s) or guardian(s) after the nature of the study has been explained and prior to any research related procedures
- Signed HIPPA compliant research authorization
Exclusion
- Participant will be excluded from the study for any of the following criteria
- Diagnosis of a hereditary aortopathy can not be confirmed
- Existence of an additional comorbid condition- including a co-existing genetic syndrome, heart failure, renal disease, rheumatologic disease, history of malignancy, thyroid disease, recent stroke, other life-limiting illness not related to cardiovascular disease.
- Extreme prematurity, \<28 weeks gestational age
Key Trial Info
Start Date :
July 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 1 2016
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT02213484
Start Date
July 1 2014
End Date
July 1 2016
Last Update
March 15 2017
Active Locations (2)
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1
Children's Hospital Colorado
Aurora, Colorado, United States, 80045
2
University of Colorado Hospital
Aurora, Colorado, United States, 80045