Status:
UNKNOWN
The Role of Th9 Cells and Eosinophils Activity in Allergic Airway Diseases
Lead Sponsor:
Lithuanian University of Health Sciences
Conditions:
Allergic Asthma
Allergic Rhinitis
Eligibility:
All Genders
18-50 years
Brief Summary
The prevalence of allergic diseases, especially airway allergic diseases, has increased dramatically over the last twenty years all over the world including Lithuania. Allergic diseases are associated...
Eligibility Criteria
Inclusion
- I. Inclusion criteria:
- Men and women between the ages of 18-50 years;
- Allergic asthma (skin prick test positive for D. pteronyssinus, 5 grass mixture or birch pollen);
- Symptoms more than one year;
- Positive Bronchial challenge with methacholine or documented completely reversible bronchial obstruction;
- Stable lung function (FEV1≥70 perc.);
- Allergic rhinitis diagnosed according ARIA criteria.
- Postmenopausal women. Premenopausal women if pregnancy test is negative
- Healthy (subjects who are not sick with acute or chronic inflammatory, infectious, oncologic or immune diseases) - control group
- Participants who gave his/her informed written consent.
- II. Exclusion criteria
- Asthma and rhinitis exacerbation;
- Clinically significant permanent allergy symptoms (ex. cat or dog dander induced allergy);
- Active airway infection 1 month prior the study;
- Used medicaments:
- Inhaled glucocorticoids intake 1 month prior the study;
- Antihistamines intake 7 days prior the study;
- Short acting β2 agonists 12 hours prior the study;
- Long acting β2 agonists 2 days prior the study;
- Leukotriene receptor antagonists prior 14 days;
- If the histamine mean wheal diameter is \<= 3 mm or control mean wheal diameter is \>= 3 mm;
- Psychiatric disorders;
- Alcohol or narcotic abuse;
- Pregnancy.
- Breast-feeding.
Exclusion
Key Trial Info
Start Date :
April 1 2013
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2015
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT02214303
Start Date
April 1 2013
End Date
December 1 2015
Last Update
August 12 2014
Active Locations (1)
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1
Lithuanian University of Health Sciences
Kaunas, Lithuania, 50009