Status:
COMPLETED
Biomarkers of Social Sensitivity in Major Depression
Lead Sponsor:
Institut National de la Santé Et de la Recherche Médicale, France
Conditions:
Major Depressive Disorder
Eligibility:
All Genders
18-60 years
Brief Summary
Major depression disorder (MDD) is a frequent and disabling mental disorder with great risk of recurrence and chronicity. Interpersonal factors are among the strongest predictors of the course and dur...
Eligibility Criteria
Inclusion
- For everybody :
- benefit social health insurance
- french speaker and reader
- can stop smoking one day
- volunteer to participate
- For 1st group :
- actual MDD diagnosed by a psychiatrist and meet the DSM IV criterias of MDD
- no antidepressant treatment or antidepressant treatment for less than 7 days.
Exclusion
- BMI \> 40
- weekly sport \> 3 hours
- pregnancy
- fever or other infection symptoms during the last month
- significant or unstable disease, especially neurologic or inflammatory.
- recent history of coronary disease, ulcer, COPD, severe dyslipemia, kidney or liver failure.
- severe smoking addiction (fagerström \> 8)
- antiinflammatory or immunomodulatory treatment during last month
- For 1st group :
- no psychiatric treatment except benzodiazepin if no severe vigilance trouble and antidepressant treatment more than 7 days
- subjects under legal protection
- constraint hospitalization
- significant suicidal risk
- resistant MDD
- psychiatric comorbidity
- For 2nd group :
- \- psychiatric disease, actual or past according to DSM IV criterias
Key Trial Info
Start Date :
October 23 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 1 2017
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT02214511
Start Date
October 23 2014
End Date
March 1 2017
Last Update
August 30 2021
Active Locations (1)
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1
ICM, Pitié Salpêtrière Hospital
Paris, France, 75013