Status:
UNKNOWN
Assessing the Efficacy of Intravenous Acetaminophen Versus the Oral Formulation for Perioperative Pain Treatment
Lead Sponsor:
Massachusetts General Hospital
Conditions:
Postoperative Pain
Eligibility:
All Genders
18+ years
Brief Summary
To compare oral (PO) to intravenous (IV) acetaminophen with postoperative pain scores, and consumptions of opiates, among orthopedic surgery patients undergoing total knee replacement with spinal anes...
Detailed Description
Intravenous acetaminophen has rapid onset and potent analgesic properties. Recent studies have shown several advantages of using intravenous acetaminophen perioperatively. However, due to its relative...
Eligibility Criteria
Inclusion
- Patients undergoing total knee replacement
- Successful spinal placement
- ≥18 years old
Exclusion
- Failed spinal anesthesia
- Chronic opiate users
- Liver disease patients
- Allergy/hypersensitivity to acetaminophen
- Patients with baseline dementia
- Patients weighing less than 50kg, history of alcohol dependence, renal impairment, opiate allergy, and pregnancy.
Key Trial Info
Start Date :
August 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
October 1 2015
Estimated Enrollment :
174 Patients enrolled
Trial Details
Trial ID
NCT02216682
Start Date
August 1 2014
End Date
October 1 2015
Last Update
August 15 2014
Active Locations (1)
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1
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114