Status:
COMPLETED
Intraocular Cytokines in Non-responders to Ranibizumab Treatment for Neovascular AMD
Lead Sponsor:
University Health Network, Toronto
Conditions:
Age Related Macular Degeneration
Eligibility:
All Genders
18+ years
Brief Summary
The purpose of this study is to evaluate the level of cytokines (which are small proteins important in cell signalling) in eye fluid (aqueous humour) in patients with wet age related macular degenerat...
Detailed Description
In the treatment of CNV (Choroidal NeoVascularization) secondary from AMD (Age Related Macular Degeneration) by using ranibizumab, patients who are non-responders can be found in approximately 1-10% o...
Eligibility Criteria
Inclusion
- Age 50 years or more
- Ranibizumab resistance/poor responder patients in all AMD entities (typical AMD, PCV and RAP) who will be treated with intravitreous ranibizumab in combination with verteporfin photodynamic therapy
- Ranibizumab resistance/poor responder patients in all AMD entity (typical AMD, PCV and RAP) who will be treated with intravitreous aflibercept injection
- AMD patient who is good response to the treatment of ranibizumab (control group)
Exclusion
- Any evidence of good response in treatment of ranibizumab,
- Uncooperative patients to intravitreal treatment
- Patients who have clinically active ocular inflammation
- Patients who have previous PDT treatment within 6 months
- Patient who previously have ocular treatment of immunosuppressive agent within 3 months
- Patient who previously have ocular treatment of steroid with in 3 months
- Patients who are currently on systemic treatment of anti-VEGF medication or immunosuppressive agents.
Key Trial Info
Start Date :
August 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2016
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT02218177
Start Date
August 1 2014
End Date
December 1 2016
Last Update
October 11 2018
Active Locations (1)
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1
Toronto Western Hospital
Toronto, Ontario, Canada, M2N4H3