Status:
COMPLETED
Health Effects of Milk Proteins in Elderly Subjects
Lead Sponsor:
University of Oslo
Collaborating Sponsors:
The Research Council of Norway
Tine
Conditions:
Healthy
Eligibility:
All Genders
70+ years
Phase:
NA
Brief Summary
The aim of the present study is to investigate effects of milk on body composition and muscle strength, inflammation, appetite, DNA damage/repair and PBMC whole genome transcriptomics in elderly subje...
Eligibility Criteria
Inclusion
- ≥ 70 years of age
- reduced gait speed or
- reduced "five times sit to stand test" or
- reduced "timed step stair test " or
- reduced grip strength
- Stable body weight (last 3 months)
- Mini Nutritional Assessment (MNA®) score ≥ 17
- Mini-mental status (MMSE-NR) score: ≥ 24
- Willing to participate according to the protocol
Exclusion
- Allergy/intolerance to milk/dairy products
- High intake of milk and yoghurt
- Physical active subjects
- Known diabetes type I or II, or HbA1c ≥ 6,5%
- Recent events of acute cardiovascular disease including stroke
- Rapidly evolving diseases (active malignancy) or history of cancer (malignant tumors) last 3 years.
- Severe inflammation-related diseases such as e.g. Crohn disease and arthritis
- Chronic obstructive pulmonary disease
- Increased blood pressure
- High intake of alcohol
- Reduced kidney function (GFR \< 45 ml/min)
- Increased hsCRP, ASAT, ALAT
- Increased or suppressed TSH
- Hormone therapy
- Systemic use of glucocorticosteroids (anti-inflammatory steroid hormones). Use of spray and inhalator use is not exclusion.
- Disability preventing physical tests
- Using medications known to affect protein metabolism
Key Trial Info
Start Date :
August 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2015
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT02218333
Start Date
August 1 2014
End Date
September 1 2015
Last Update
October 19 2015
Active Locations (1)
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1
University of Oslo
Oslo, Post Box 1046, Blindern, Norway, 0317