Status:
UNKNOWN
Performance Evaluation of the Micromedic BRONJ Risk Assessment in Vitro Diagnostic Assay
Lead Sponsor:
Micromedic Technologies Ltd
Conditions:
Bisphosphonate-related Osteonecrosis of the Jaw
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
To evaluate the performance of the Micromedic BRONJ Risk Assessment in vitro assay (the "BRONJ Assay") in identifying Multiple Myeloma (MM) and/or other cancer subjects at risk for developing Bisphosp...
Detailed Description
The Micromedic BRONJ Assay is intended for the qualitative analysis of genetic changes which may be indicative of increased risk to develop BRONJ osteonecrosis of the jaw (ONJ) following IV administra...
Eligibility Criteria
Inclusion
- Inclusion Criteria Study Group (all of the following):
- Subject is ≥18 years old
- Subject is or was a Multiple Myeloma and/or other cancer patient who is or has been IV treated with the BP zoledronic acid and/or pamidronate disodium; Or; Subject is or was a Multiple Myeloma and/or other cancer patient who is or has been IV treated with the BP zoledronic acid and/or pamidronate disodium and was also treated by oral BP such as sodium alendronate, and in the opinion of the PI, IV treatment was significant enough to be considered as the cause for BRONJ
- Subject has been diagnosed with BRONJ at stages 1 or 2 or 3 according to AAOMS (American Association of Oral and Maxillofacial Surgeons)
- Subject has signed the informed consent or consent can be waived
- Inclusion Criteria Control Group (all of the following):
- Subject is ≥18 years old
- Subject is or was a Multiple Myeloma and/or other cancer patient who is, or has been IV treated with the BP zoledronic acid and/or pamidronate disodium for at least two (2) years (continuously or cumulatively)
- Subject has not developed any signs or symptoms of BRONJ
- Subject has signed the informed consent or consent can be waived
Exclusion
- Subject has been treated with irradiation to the jaws or head and neck at levels exceeding 35 Gy
- Pregnant or lactating women
- Subject has been treated with either bevacizumab or sunitimib
- Subject has been treated with Allogeneic hematopoietic stem cell transplantation (HSCT)
Key Trial Info
Start Date :
January 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2014
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT02218554
Start Date
January 1 2012
End Date
December 1 2014
Last Update
August 18 2014
Active Locations (2)
Enter a location and click search to find clinical trials sorted by distance.
1
Sheba Medical Center
Tel Litwinsky, Israel
2
Sheba Medical Center
Tel Litwinsky, Israel