Status:
COMPLETED
Psychosis and Affective Research Domains and Intermediate Phenotypes
Lead Sponsor:
University of Texas Southwestern Medical Center
Collaborating Sponsors:
Beth Israel Deaconess Medical Center
Hartford Hospital
Conditions:
Bipolar I Disorder, Unspecified, With Psychotic Features
Bipolar I Disorder, Unspecified, Without Psychotic Features
Eligibility:
All Genders
18-60 years
Brief Summary
The objective of this multi-site research collaboration is to test the manifestation and distribution of biological markers for psychosis and affect dimensions across the schizophrenia/bipolar (SZ-BD)...
Detailed Description
The B-SNIP research consortium previously obtained dense phenotypes across the psychosis spectrum in an effort to observe features both (i) distinctive to and (ii) shared between DSM-type categorical ...
Eligibility Criteria
Inclusion
- Must provide consent to participate after being fully informed about the study procedures and the information to be collected
- Males and females
- Ages 18-60 years old
- All races and ethnicities
- Probands: Must meet DSM-IV criteria for bipolar I disorder with or without lifetime history of psychosis; Healthy Controls: Must have no personal history of any psychotic or mood disorder, or a family history of psychotic or recurrent mood disorder among their first-degree relatives
- Must be judged to be capable of completing the study procedures by study investigators
- Must be able to read, speak, and understand English
Exclusion
- An estimated IQ\<70
- Major neurological or cognitive disorder (e.g., seizure disorder, traumatic brain injury, cerebrovascular disease, pervasive developmental disorder)
- Serious medical, neuro-ophthalmological, or neurological illness that could affect CNS functioning (e.g., decompensated cardiovascular disease, decompensated chronic obstructive pulmonary disease, late stages of diabetes, AIDS)
- DSM-IV diagnosis of alcohol or illicit substance abuse within 1 month, or alcohol or substance dependence within 3 months, or extensive history of past substance use
- Women who are pregnant (due to unknown risks related to MRI exposure)
- Presence of medical (e.g., artificial joints, brain aneurism clips, surgical pins, rods, wires, implants) or non-medical (e.g., metal piercing) irremovable metallic objects on/inside body (due to MRI-relevant risks)
Key Trial Info
Start Date :
April 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2017
Estimated Enrollment :
113 Patients enrolled
Trial Details
Trial ID
NCT02218853
Start Date
April 1 2014
End Date
December 1 2017
Last Update
September 19 2019
Active Locations (1)
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1
UT Southwestern Medical Center
Dallas, Texas, United States, 75390