Status:
COMPLETED
Biomarkers of Remission in Rheumatoid Arthritis (BioRRA)
Lead Sponsor:
Newcastle-upon-Tyne Hospitals NHS Trust
Collaborating Sponsors:
Newcastle University
Wellcome Trust
Conditions:
Rheumatoid Arthritis
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Rheumatoid arthritis is a common condition affecting approximately 1% of the United Kingdom population; it is an autoimmune disease where the body's natural defences (the immune system) attack the bod...
Eligibility Criteria
Inclusion
- Clinical diagnosis of rheumatoid arthritis made by consultant rheumatologist at least 12 months previously
- Current single or combination use of methotrexate, sulphasalazine and/or hydroxychloroquine
- Arthritis currently in remission, as judged clinically by referring healthcare professional
- Willing to consider DMARD withdrawal
Exclusion
- Use of biologic therapy within the past 6 months
- Received steroids within past 3 months (enteral, parenteral or intra-articular)
- Use of any DMARD other than methotrexate, sulphasalazine or hydroxychloroquine within the past 6 months (or past 12 months for leflunomide)
- Current pregnancy, or pregnancy planned within next 6 months
- Current participation within another clinical trial
- Inability to provide informed consent
Key Trial Info
Start Date :
August 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2017
Estimated Enrollment :
74 Patients enrolled
Trial Details
Trial ID
NCT02219347
Start Date
August 1 2014
End Date
August 1 2017
Last Update
November 6 2017
Active Locations (1)
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1
Newcastle NIHR Clinical Research Facility, Royal Victoria Infirmary, Newcastle upon Tyne Hospitals NHS Foundation Trust
Newcastle upon Tyne, Tyne & Wear, United Kingdom, NE1 4LP