Status:
COMPLETED
Continuous Adductor Canal Nerve Blocks: Relative Effects of a Basal Infusion v. Hourly Bolus Doses
Lead Sponsor:
University of California, San Diego
Conditions:
Healthy Human Volunteers
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
Patients usually experience moderate-to-severe pain following the knee replacement that is often treated with a femoral nerve block (injection of numbing medicine placed around the main nerve of the k...
Detailed Description
This investigation will be a randomized, observer-masked, controlled, split-body, human-subjects clinical trial. Of note, we will be using standard-of-care local anesthetics under their FDA approved p...
Eligibility Criteria
Inclusion
- (1) age ≥ 18 years; and (2) willing to have bilateral adductor canal perineural catheters placed with subsequent ropivacaine administration and motor/sensory testing for 14 hours, requiring an overnight stay in the UCSD CTRI-CCR to allow dissipation of local anesthetic infusion effects by the following morning.
Exclusion
- (1) current daily analgesic use; (2) opioid use within the previous 4 weeks; (3) any neuro-muscular deficit of either femoral nerves and/or quadriceps muscles; (4) morbid obesity \[weight \> 35 kg/m2\]; (5) pregnancy (as determined by a urine pregnancy test prior to any study interventions); and (6) incarceration. We expect to recruit a maximum of 30 healthy volunteers; with a target goal of 24 for the analysis. Selection for inclusion will not be based on gender, race, or socioeconomic status. The study population of interest includes men and women of all races and socioeconomic status. There will be no participants from vulnerable populations, such as pregnant women, children, or prisoners.
Key Trial Info
Start Date :
August 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2014
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT02219438
Start Date
August 1 2014
End Date
December 1 2014
Last Update
March 19 2021
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University California San Diego
San Diego, California, United States, 92103