Status:
COMPLETED
Dynamic Assessment of Right Ventricular Function With Inhaled Nitric Oxide During Cardiac MRI
Lead Sponsor:
Vanderbilt University
Collaborating Sponsors:
Mallinckrodt
Conditions:
Pulmonary Vascular Disorder
Eligibility:
All Genders
18+ years
Phase:
EARLY_PHASE1
Brief Summary
The purpose of the study is to measure RV ejection fraction (RVEF), pulmonary flow, and pulmonary perfusion before and after exposure to inhaled nitric oxide in patients with pulmonary arterial hypert...
Eligibility Criteria
Inclusion
- Patients age 18 or older of the Vanderbilt Center for Pulmonary Vascular Disease. Vasodilator-responsive patients will be identified based on prior response to inhaled nitric oxide during invasive right heart catheterization
- Healthy subjects age 18 or older not known to have cardiopulmonary disease
Exclusion
- Standard conventional contraindications for cardiac magnetic resonance (CMR) imaging
- Allergy or contraindication to Magnevist (gadopentetate dimeglumine) contrast
- Concurrent intravenous epoprostenol infusion in whom performance of CMR is cumbersome
- Pregnant women
Key Trial Info
Start Date :
July 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2017
Estimated Enrollment :
17 Patients enrolled
Trial Details
Trial ID
NCT02220023
Start Date
July 1 2014
End Date
February 1 2017
Last Update
February 13 2017
Active Locations (1)
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1
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37232