Status:
UNKNOWN
RCT of the 4mm vs. the 8mm Collimator for GKR of Brain Micrometastases
Lead Sponsor:
University College, London
Collaborating Sponsors:
University College London Hospitals
Conditions:
Brain Micrometastases
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Gamma Knife Radiosurgery (GKR) is a well-established treatment modality for brain metastasis (Chiou 2013; Salvetti, Nagaraja et al. 2013). Large multicentre series have been published on patients with...
Eligibility Criteria
Inclusion
- Adult patients with brain metastasis from any primary tumour receiving GKR.
- All intracranial micro-metastases including lesions located in the cerebral hemispheres, thalamus, basal ganglia and cerebellum and excluding lesions located in the brain stem below the level of the superior colliculi.
- Target volume \< 0.14 cc3 and maximum diameter \< 7 mm.
- The subject consents to participate in the study.
Exclusion
- Inability to consent
- Younger than 18 years of age.
- Lesions in the brainstem (below the level of the superior colliculi) are better treated with the 4 mm collimator and they will be excluded from the study.
- Patients with more than 25 brain lesions suitable for randomisation will be excluded from the study.
- Co-morbidity or previous treatment such as surgery, chemotherapy or WBRT is not to be considered as exclusion criteria.
- Pregnancy in the context of brain metastases is not a contraindication for GKR, and therefore it will not be considered as exclusion criteria for this trial.
Key Trial Info
Start Date :
September 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 1 2021
Estimated Enrollment :
298 Patients enrolled
Trial Details
Trial ID
NCT02220127
Start Date
September 1 2014
End Date
April 1 2021
Last Update
March 20 2015
Active Locations (3)
Enter a location and click search to find clinical trials sorted by distance.
1
Gamma Knife Centre at BUPA Cromwell Hospital
London, United Kingdom, SW5 0TU
2
The Gamma Knife Centre at Queen Square
London, United Kingdom, WC1N 3BG
3
BMI Thornbury Hospital
Sheffield, United Kingdom, S10 3BR