Status:
COMPLETED
Molecular, Cytological Features and Genetic Susceptibility of COPD Attributable to Different Environmental Exposures
Lead Sponsor:
Novosibirsk City Hospital #2
Collaborating Sponsors:
Siberian Branch of the Russian Academy of Medical Sciences
Conditions:
Chronic Obstructive Pulmonary Disease
Eligibility:
MALE
40-75 years
Brief Summary
The objective of this study is to investigate molecular, cytological and genetic features of occupational chronic obstructive pulmonary disease (COPD) in conditions of different occupational exposures...
Detailed Description
Study rationale: The main risk factors of COPD are tobacco smoking, biomass smoking and occupational factors. Tobacco smoking is well-known risk factor so tobacco induced COPD is completely establishe...
Eligibility Criteria
Inclusion
- Post- bronchodilator forced Expiratory Volume in 1 second (FEV1)/Forced Vital Capacity (FVC) ratio less than 0.7
- Stable phase of COPD
- History of exposure to respirable silica dust, nonsmokers with absence of passive exposure to tobacco smoke or history of exposure to polycyclic aromatic hydrocarbons exhaust, nonsmokers with absence of passive exposure to tobacco smoke or current tobacco smokers without history of occupational exposure
- COPD risk factor exposure (occupational or tobacco smoke) duration not less than 12 months
- Male
- Caucasian
- Age of 40 - 75 years old
- Control group - healthy people
Exclusion
- history of biomass smoke exposure
- age less than 40 and above 75 years old
- current COPD exacerbation
- concomitant asthma
- tuberculosis and other pulmonary diseases
- allergic and autoimmune disorders
- active infections
- immunodeficiency, including HIV infection
- parasitological diseases
- malignancies
- lack of informed consent
Key Trial Info
Start Date :
August 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 1 2014
Estimated Enrollment :
352 Patients enrolled
Trial Details
Trial ID
NCT02220387
Start Date
August 1 2014
End Date
September 1 2014
Last Update
October 6 2015
Active Locations (1)
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1
Novosibirsk City Hospital #2
Novosibirsk, Russia, 630084