Status:
TERMINATED
Hyperpolarized Xenon-129 Magnetic Resonance Imaging and Spectroscopy of Brown Fat: Healthy Adult Volunteer Pilot Study
Lead Sponsor:
University of North Carolina, Chapel Hill
Collaborating Sponsors:
North Carolina Translational and Clinical Sciences Institute
Conditions:
Obesity
Eligibility:
All Genders
18-60 years
Phase:
PHASE1
Brief Summary
The primary goal of this study is to evaluate the feasibility of detecting Brown Adipose Tissue (BAT) in healthy subjects by using hyperpolarized xenon gas MRI. In this pilot study, MRI of BAT of hea...
Detailed Description
In the fight against obesity, brown adipose tissue (BAT) is considered to be the newest target. The hypothesis is that this tissue is partially responsible for the imbalance between energy intake and ...
Eligibility Criteria
Inclusion
- Ability to give informed consent
- Willing to participate in this study
- Male or female ≥ 18 years of age at the time of the interview.
- Subject has no diagnosed pulmonary condition
- Subject has not smoked in the previous 5 years
- Smoking history, if any, is less than or equal to 5 pack-years
- Written informed consent (and assent when applicable) obtained from subject or subject's
- legal representative and ability for subject to comply with the requirements of the study
- Healthy subject that may or may not have undergone an fluorodeoxyglucose -Positron Emission Tomography (PET) scan
Exclusion
- Any contraindication to MRI (presence of any non-removable metal implant, stents, pacemaker, clips, staples, or piercings, etc. )
- Subject does not fit in the magnet
- Pregnancy or breast feeding
- Severe claustrophobia
- Subject is less than 18 years old
- MRI is contraindicated based on responses to MRI screening questionnaire
- Subject is pregnant or lactating
- Respiratory illness of a bacterial or viral etiology within 15 days of MRI
- Subject has received an investigational medicinal product (not including 129Xe) within 30 days of MRI
- Subject has any form of known cardiovascular disease
- Subject cannot hold their breath for 15 seconds
- Subject deemed unlikely to be able to comply with instructions during imaging
- Subject is taking beta blockers
- Subject underwent an fluorodeoxyglucose-PET examination less than one week before the HP xenon MRI scan
Key Trial Info
Start Date :
September 1 2015
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2016
Estimated Enrollment :
17 Patients enrolled
Trial Details
Trial ID
NCT02220426
Start Date
September 1 2015
End Date
July 1 2016
Last Update
November 25 2025
Active Locations (1)
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1
Biomedical Research Imaging Center
Chapel Hill, North Carolina, United States, 27599-7513