Status:
COMPLETED
Control and Reward Circuits in Obsessive Compulsive Disorder
Lead Sponsor:
New York State Psychiatric Institute
Conditions:
Obsessive-Compulsive Disorder
Eligibility:
All Genders
18-55 years
Phase:
NA
Brief Summary
The purpose of this study is to examine the brain functioning of OCD patients and healthy controls before and after treatment with Exposure and Response Prevention (EXRP) therapy.
Detailed Description
The capacity to coordinate thoughts and actions to execute goal-directed behaviors (cognitive control) and the capacity to anticipate, respond to, and learn from reward (reward processing) are key pro...
Eligibility Criteria
Inclusion
- Inclusion Criteria for Patients:
- Male and females with OCD aged 18-55
- Diagnostic and Statistical Manual of Mental Disorders (DSM-5) Diagnosis of OCD
- Not on psychotropic medication
- Exclusion Criteria for Patients:
- Presence of metallic devices or dental braces in the body that are contraindicators for MR imaging
- Comorbid psychiatric conditions that significantly elevate the risk of study participation (e.g. psychotic disorders, bipolar disorder, evidence of dementia or other cognitive disorder, suicidality)
- Unstable medical conditions that need attention and would make participation in the study unsafe (e.g. very high blood pressure)
- Use of psychotropic medication
- Females who are pregnant or post-menopausal
- Inclusion Criteria for Healthy Volunteers
- \- Male and females aged 18-55
- Exclusion Criteria for Healthy Volunteers
- Presence of metallic devices or dental braces in the body that are contraindicators for MR imaging
- Any psychiatric diagnosis
- Use of psychotropic medication
- Diagnosis of OCD in a first degree relative
- Females who are pregnant or post-menopausal
- Unstable medical conditions that need attention and would make participation in the study unsafe (e.g. very high blood pressure)
Exclusion
Key Trial Info
Start Date :
October 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2018
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT02221518
Start Date
October 1 2014
End Date
August 1 2018
Last Update
March 13 2019
Active Locations (1)
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1
NY State Psychiatric Institute
New York, New York, United States, 10032