Status:
COMPLETED
Vitamin D and Muscle Metabolic Function
Lead Sponsor:
David Travis Thomas
Conditions:
Healthy
Eligibility:
All Genders
60+ years
Phase:
NA
Brief Summary
The purpose of this study is to identify the magnitude of muscle lipid redistribution and muscle oxygen use in individuals 60 years old or older following combined treatment of vitamin D repletion and...
Detailed Description
The investigators plan to recruit approximately 56 aged individuals with vitamin D insufficiency for a 13 week trial. All subjects will be 60 years of age or older. Participants will be randomized to ...
Eligibility Criteria
Inclusion
- Age: 60 and older
- BMI: 18.5-29
- Communicates fluently in English
Exclusion
- Metal implant not suitable for MRI
- Any form of hormone replacement therapy
- Engage in more than 1 hr/week of vigorous activity
- Participated in a high-intensity resistance or aerobic training program in the last 3 months
- Lower extremity injury or surgery in the past 3 months
- Foot sores or bone conditions severely limiting ability to move or perform exercise or joint pain made worse by mild exercise
- Diabetes, inflammatory bowel disease, renal disease or uncontrolled hypertension.
- Currently have or had a history of cardiovascular or pulmonary disease that would preclude the involvement in the performance of exercise
- History of myopathy (including congenital myopathies)
- History of neurological conditions related to spinal derangement, disk disease, peripheral neuropathies, tremor and rigidity
- Past medical history of hyperparathyroidism, kidney stones or rhabdomyolysis
- Currently receiving treatment for vitamin D deficiency
- Vitamin D level \>30ng/mL
- Currently smoking
Key Trial Info
Start Date :
September 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2018
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT02221596
Start Date
September 1 2014
End Date
March 1 2018
Last Update
March 15 2018
Active Locations (1)
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1
University of Kentucky
Lexington, Kentucky, United States, 40536