Status:
WITHDRAWN
The Gut Microbiome in Diverticulitis and Diverticulosis
Lead Sponsor:
King's College Hospital NHS Trust
Conditions:
Diverticulitis
Diverticulosis
Eligibility:
All Genders
18-90 years
Brief Summary
Colonic diverticula are outpouchings of the large bowel, and they occur in up to 60% of people over 60 years of age. About 10-25% of patients with diverticula will have symptoms. These can range from ...
Detailed Description
Diverticulosis affects 60% of people over 60 and roughly 10-25% of individuals will have symptoms, ranging from acute diverticulitis requiring emergent intervention to symptomatic diverticular disease...
Eligibility Criteria
Inclusion
- Groups A and B. Patients with acute diverticulitis - patients presenting to A\&E at King's College Hospital with new onset abdominal pain, with or without a known diagnosis of diverticulitis
- Groups C and D. Patients with asymptomatic diverticulosis and normal controls
- \- Patients being assessed through the 2ww Colorectal Cancer pathway with a chief complaint of fresh PR bleeding and no other 'red flag' symptoms, who are not overly anxious over their diagnosis as assessed by a physician outside the study team.
Exclusion
- Groups A and B. Patients with acute diverticulitis
- Patients in extremis- e.g. systolic blood pressure less than 80 on arrival or pulse greater than 115
- Patients who have received antibiotics in the three months prior to presentation.
- Vulnerable patient populations
- Groups C and D. Patients with asymptomatic diverticulosis and normal controls
- Patients with high levels of pre-test anxiety, as determined by their assessing physician, outside the study team
- Patients who received antibiotics for any reason in the 3 months prior to inclusion
- Vulnerable patient populations
Key Trial Info
Start Date :
June 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 1 2021
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT02221713
Start Date
June 1 2020
End Date
May 1 2021
Last Update
April 2 2020
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
King's College Hospital
London, United Kingdom, se59rs