Status:
TERMINATED
Study to Evaluate the Preliminary Safety, Efficacy, PK and PD of Bryostatin 1 in Patients With Alzheimer's Disease
Lead Sponsor:
Neurotrope Bioscience, Inc.
Collaborating Sponsors:
Blanchette Rockefeller Neurosciences Insitute
Conditions:
Alzheimer's Disease
Eligibility:
All Genders
50-85 years
Phase:
PHASE1
PHASE2
Brief Summary
This study is being done to evaluate the safety, tolerability and potential effectiveness of a new investigational drug, bryostatin 1, in patients with Alzheimer's disease (AD).
Detailed Description
This study is a single center, randomized, double-blind, placebo-controlled, parallel groups trial in patients with AD. Each subject enrolled in the trial will be randomized to receive a single IV dos...
Eligibility Criteria
Inclusion
- Male or female, age 50 - 85 yrs. Females are non-childbearing potential
- Patient must have a cognitive deficit present for at least 1 year and meet diagnostic criteria for probable Alzheimer's Disease Dementia by NIA-AA criteria or prodromal Alzheimer's Disease
- Mini Mental State Exam score of 16-26
- Ability to walk, at least with an assistive device
- Vision and hearing sufficient to comply with testing
- Normal cognitive and social functioning prior to onset of dementia, with evidence of progressive symptoms from patient or informant
- Consistent caregiver to accompany patient to visits
- Sufficient basic education to be able to complete the cognitive assessments
- Living outside an institution
Exclusion
- Dementia due to any condition other than AD, including vascular dementia
- Significant neuroimaging abnormalities, previously known or discovered on screening MRI scan,
- Evidence of clinically significant unstable cardiovascular, renal, hepatic, gastrointestinal, neurological, or metabolic disease within the past 6 months
- Use of any drug within 14 days prior to randomization unless the dose of the drug and the condition being treated have been stable for at least 30 days and are expected to remain stable during the study
- Use of tobacco products or nicotine-containing products within 3 months before Day 1
- Use of high dose vitamin E, or valproic acid
- Any medical or psychiatric condition that may require medication or surgical treatment during the study
- Life expectancy less than 6 months
- Use of an investigational drug within 2 months prior to the screening visit
- Clinically significant neurological disease other than AD
- Major depression, alcohol or drug dependence or suicidality
- Psychotic episodes requiring hospitalization or antipsychotic therapy for more than 2 weeks within the past 10 years, not linked to AD
- Agitation sufficient to preclude participation in this trial
- Epilepsy or anti-epileptic drug therapy
- Abnormal laboratory tests that might point to another etiology for dementia;
- Acute or poorly controlled medical illness
- Likelihood, according to clinical judgment, of being transferred to a nursing home within 6 months
Key Trial Info
Start Date :
June 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2014
Estimated Enrollment :
9 Patients enrolled
Trial Details
Trial ID
NCT02221947
Start Date
June 1 2014
End Date
December 1 2014
Last Update
November 6 2017
Active Locations (1)
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1
California Clinical Trials Medical Center
Glendale, California, United States, 91206