Status:
RECRUITING
Improving Radical Treatment Through MRI Evaluation of Pelvic Sigmoid Cancers
Lead Sponsor:
Imperial College London
Collaborating Sponsors:
Pelican Cancer Foundation
Conditions:
Cancer
Colorectal Neoplasms
Eligibility:
All Genders
16+ years
Phase:
NA
Brief Summary
Patients with suspected or proven sigmoid colon adenocarcinoma, eligible for curative treatment whose MRI can be reviewed prior to surgery and has no decision regarding radical treatment are eligible....
Detailed Description
A randomised phase II multicentre trial, IMPRESS will determine whether the use of MRI imaging in staging sigmoid cancers results in a change to the treatment plan by identifying more high risk tumour...
Eligibility Criteria
Inclusion
- Have a suspected or proven sigmoid colon adenocarcinoma
- Is eligible for curative treatment
- Has no irresectable metastatic disease
- MRI can be reviewed by an MDT prior to surgery
- Has no decision regarding radical treatment
- Have provided written informed consent to participate in the study
- Be aged 16 years or over
Exclusion
- Have metastatic disease (including resectable liver metastases)
- Have a synchronous second malignancy
- Are contraindicated for MRI
- Are contraindicated for or have allergy to Buscopan (e.g. glaucoma, small or large bowel obstruction, GFR\<30)
- Have severe co-morbidities or previous medical history that prevent the application of eventual chemo/radiotherapy
Key Trial Info
Start Date :
August 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2031
Estimated Enrollment :
244 Patients enrolled
Trial Details
Trial ID
NCT02222844
Start Date
August 1 2014
End Date
December 1 2031
Last Update
October 17 2024
Active Locations (16)
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1
Hinchingbrooke Hospital
Huntingdon, Cambridgeshire, United Kingdom, PE29 6NT
2
Leighton Hospital
Crewe, Cheshire, United Kingdom, CW1 4QJ
3
University Hospital of North Tees
Stockton-on-Tees, County Durham, United Kingdom, TS19 8PE
4
Croydon University Hospital
Thornton Heath, Croydon, United Kingdom, CR7 7YE