Status:
COMPLETED
Effects of PGS in Infertile Female Patients With RPL
Lead Sponsor:
ShangHai Ji Ai Genetics & IVF Institute
Conditions:
Infertility, Female
Abortion, Habitual
Eligibility:
FEMALE
18-48 years
Phase:
NA
Brief Summary
Recurrent pregnancy loss (RPL) is a multifactorial disorder which affects about 1% of all couples and challenges both patients and clinicians technically and emotionally. IVF clinics see higher preval...
Eligibility Criteria
Inclusion
- Women 18-48 years of age who are scheduled for IVF or ICSI with a history of recurrent spontaneous abortion (continous miscarriage occurred earlier than 20 weeks of gestation for equal or greater than 2 times) in our IVF institute while meeting the following criteria:
- regular menstrual cycles and normal level of E2, P, FSH, LH, T, RPL in the early follicular phase;
- no history of hormone medicine application in the last 3 months;
- no history of poison contact;
- normal uterine and adnexal ultrasonography;
- TORCH(-), chlamydia(-), mycoplasma(-), normal leucorrhoea routine, anti-phospholipid antibody (-), antinuclear antibody(-);
- for the couple, no blood type incompatibility or ABO antibody IgG≤1：64 and normal blood chromosome analysis.
Exclusion
- hydrosalpinx without operation; endometriosis; polycystic ovary syndrome; adenomyosis; uterine leiomyomata(submucous myoma or non-submucous myoma which size was exceed 4cm and/or with the compressed endometrium);uterine cavity lesions(such as uterine malformation, intrauterine adhesions, the septate uterus, endometritis etc);
- the former abortion is because of luteal phase defect without treatment;
- thyroid dysfunction or increased CA125 level;
- acute inflammation of genitourinary system or STD carriers;
- unable to comply with the study procedures.
Key Trial Info
Start Date :
August 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 30 2017
Estimated Enrollment :
189 Patients enrolled
Trial Details
Trial ID
NCT02223221
Start Date
August 1 2014
End Date
April 30 2017
Last Update
July 11 2017
Active Locations (1)
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1
Shanghai Jiai Genetics & IVF Institute
Shanghai, China, 200011