Status:
UNKNOWN
Effects of Different Doses of Dexmedetomidine on Postoperative Cognitive Dysfunction in Elderly Hypertensive Patients
Lead Sponsor:
First Affiliated Hospital Xi'an Jiaotong University
Conditions:
Postoperative Cognitive Dysfunction
Eligibility:
All Genders
65-80 years
Phase:
PHASE4
Brief Summary
The purpose of this study is to identify the effects of different doses of dexmedetomidine on postoperative cognitive dysfunction in elderly hypertensive patients
Eligibility Criteria
Inclusion
- Written informed consent
- Elective gastrointestinal surgery
- American Society of Anesthesiologists class II to III
- Aged between 65 and 80 years old
- Weight between 45 and 75 kilogram,Body Mass Index between 19 and 24 kg.m-2
- With primary hypertension reaching or more than 1 year
- Normal cognitive function,mini-mental state examination more than 27
Exclusion
- Severe arrhythmia,atrioventricular block and secondary hypertension
- Liver and kidney dysfunction,pulmonary disease,endocrine disease
- Suspected or confirmed difficult airway
- Any disease or pathologic change will interfere study result
- Inability to exchange with serious visual and hearing impairment
- Long term use of sedative-hypnotic drugs and antidepressant drug
- Addicted to alcohol, tobacco or drug
- Neuromuscular disease
- Suspected of malignant hyperthermia
- Allergic to investigational products or with other contraindication
- Participated in other study within 30 days
Key Trial Info
Start Date :
September 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2015
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT02224443
Start Date
September 1 2014
End Date
September 1 2015
Last Update
August 25 2014
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