Status:
COMPLETED
Imaging Collaterals in Acute Stroke (iCAS)
Lead Sponsor:
Stanford University
Collaborating Sponsors:
Swedish Medical Center
University of Pittsburgh
Conditions:
Stroke, Acute
Eligibility:
All Genders
18+ years
Brief Summary
Stroke is caused by a sudden blockage of a blood vessel that delivers blood to the brain. Unblocking the blood vessel with a blood clot removal device restores blood flow and if done quickly may preve...
Detailed Description
Intravenous tissue plasminogen activator (IV tPA) is the standard of care treatment for stroke patients when treatment can be initiated within 3 hours after symptom onset. Unfortunately, only a very s...
Eligibility Criteria
Inclusion
- Inclusion Criteria
- Age 18 and older
- Clinical diagnosis of ischemic stroke and an associated score on the NIHSS of 5 or more points
- Planned to undergo (or has undergone) intra-arterial (IA) thrombectomy and/or thrombolysis for acute hemispheric stroke. (Either as primary therapy or as adjuvant therapy following intravenous tPA treatment)
- Planned to undergo or has undergone an MR brain scan including MR perfusion imaging (ASL \& bolus PWI) and MR angiography of the circle of Willis prior to IA therapy
- Intra-arterial thrombectomy can be started within 90 minutes of completion of the MR perfusion scan and within 24 hours of symptom onset (Start of IA therapy is defined as the time of insertion of the femoral artery sheath; Time of brain scan is defined as the time that the scan is completed)
- Able to obtain informed consent
- Exclusion Criteria
- Any pre-existing illness resulting in a modified Rankin Scale Score of 2 or higher prior to the qualifying stroke
- Creatinine clearance \< 40 ml/min based on the NIDDK four-variable MDRD method (non-weight based)
- Documented allergy to MR contrast agent
- MRI contraindications (pacemaker, etc.)
- Pregnancy
Exclusion
Key Trial Info
Start Date :
September 1 2013
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 31 2019
Estimated Enrollment :
187 Patients enrolled
Trial Details
Trial ID
NCT02225730
Start Date
September 1 2013
End Date
October 31 2019
Last Update
March 19 2020
Active Locations (4)
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1
Eden Medical Center
Castro Valley, California, United States, 94546
2
Stanford University Medical Center
Stanford, California, United States, 94035
3
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15213
4
Swedish Hospital
Seattle, Washington, United States, 98122