Status:
COMPLETED
Quantitative MR Methods for Lipid Emulsions
Lead Sponsor:
University of Zurich
Conditions:
Healthy
Eligibility:
All Genders
18-50 years
Phase:
EARLY_PHASE1
Brief Summary
Quantitative MR methods will be validated for the non-invasive imaging of GI processing of lipid emulsions in 18 (12+6) healthy subjects. Validation is performed by a randomized single blind two-armed...
Detailed Description
Participants will be given two lipid emulsions with different physicochemical composition in randomized order at two separate visits. A nasogastric tube will be applied for intragastric lipid emulsion...
Eligibility Criteria
Inclusion
- Men and women between age 18 and 50
- BMI 18-25 kg/m²
- Written informed consent
Exclusion
- History of GI, cardiorespiratory (including arterial hypertension), hematologic, renal, atopic, alimentary or psychiatric disorder, panic attacks, diabetes, drug or alcohol abuse
- Prior abdominal surgery other than uncomplicated appendectomy or hernia repair
- Requiring medication that might alter gut function, including anticholinergics, calcium channel blockers, beta blockers, laxatives, prokinetics, proton-pump inhibitors, non-steroidal anti-inflammatory drugs
- Presence of metallic implants, devices or metallic foreign bodies
- Pregnancy and lactation (female participants of child bearing age will receive a pregnancy test prior to study)
- Claustrophobia
- Regular smoking or consumption of alcohol and drugs
- Uncertainty about the willingness or ability of the participant to comply with the protocol requirements
Key Trial Info
Start Date :
August 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2015
Estimated Enrollment :
22 Patients enrolled
Trial Details
Trial ID
NCT02226029
Start Date
August 1 2014
End Date
March 1 2015
Last Update
April 9 2015
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Division of Gastroenterology and Hepatology, University Hopsital Zurich
Zurich, Canton of Zurich, Switzerland, 8091