Status:
COMPLETED
Investigating the Mechanisms of Mindfulness-based Cognitive Therapy (MBCT)
Lead Sponsor:
University of Manchester
Conditions:
Major Depression (in Remission)
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
This research will investigate the neuropsychological mechanisms underlying the eight-week Mindfulness-based Cognitive Therapy (MBCT) programme. Participants in remission from depression will be seen...
Detailed Description
There will be three groups in total. * The first group will take 36 participants in remission from major depression (rMDD) through the 8 week MBCT program. * A control group of 36 rMDD participants w...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Participants with remitted depression (rMDD):
- At least two previous episodes of DSM-IV major depression in adulthood, diagnosed using the Mini International Neuropsychiatric Interview (M.I.N.I).
- Full or partial remission for at least three months with two depressive episodes within the last five years.
- A score of less than or equal to 12 on the Montgomery Asberg Depression Rating Scale (MADRS) mood assessment.
- If on medication, no recent or planned major changes
- Healthy volunteers:
- In good psychological health screened with the M.I.N.I
- All participants:
- in good physical health (to reduce risk of confounding physical health problems).
- sufficiently fluent in English to ensure valid understanding and completion of the tasks.
- minimum I.Q level of 80 to ensure sufficient understanding of the neurocognitive tasks administered.
- colour vision and acuity within normal/corrected to normal limits.
- Exclusion criteria:
- Any current mental health diagnosis (DSM-IV diagnosis including current major depression, bipolar disorder, psychosis, Obsessive Compulsive Disorder (OCD), substance abuse or dependence, eating disorders)
- Physical health or neurological disorders that might interfere with the interpretation of the tasks, including a history of significant head injury.
- In addition healthy volunteers will be without a history mental health disorders (DSM-IV)
- Current or previous experience of mindfulness-based treatments or extensive cognitive behavioural treatment, or planned participation in psychological treatments during the key time for the study (between pre and post visits).
- Planned major alteration in drug treatment for depression between pre and post visits.
Exclusion
Key Trial Info
Start Date :
October 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2017
Estimated Enrollment :
112 Patients enrolled
Trial Details
Trial ID
NCT02226042
Start Date
October 1 2014
End Date
October 1 2017
Last Update
May 3 2018
Active Locations (1)
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1
University of Manchester
Manchester, Greater Manchester, United Kingdom, M13 9PT