Status:
COMPLETED
An Investigation Into the Cardiovascular Risk and Aetiology of CKDu in Sri Lanka
Lead Sponsor:
University of Edinburgh
Collaborating Sponsors:
Rajarata University, Sri Lanka
Conditions:
CKDu
Arterial Stiffness
Eligibility:
All Genders
18-85 years
Brief Summary
1. We hypothesise that CKDu patients will have increased arterial stiffness and thus increased all-cause and cardiovascular mortality. The first objective of this study is to recruit a cohort of \~ 50...
Detailed Description
Chronic kidney disease (CKD) is one of the leading causes of hospital admission, clinic attendance and mortality in some provinces of Sri Lanka. In central and southern provinces increased incidence i...
Eligibility Criteria
Inclusion
- CKDu (CKD unknown aetiology) patients:
- Inclusion Criteria
- Age 18- 85 years
- Attend CKDu clinic in Anuradhapura or Padavi-Sri Pura
- Evidence of renal dysfunction: proteinuria, raised serum creatinine
- Able to understand information given and happy to give consent
- Exclusion Criteria
- Subjects who are on dialysis
- History of diabetes
- History of major cardiac (including MI), respiratory (including asthma \& COPD) or neurological disease
- Pregnant
- History of significant hypertension (\>140/90mmHg despite anti-hypertensives or \>160/100mmHg untreated)
- History of glomerulonephritis or other known cause of renal disease
- Inclusion criteria for healthy volunteers:
- Age 18- 85 years
- Present in Anuradhapura teaching hospital as a visitor/carer of patient in ward or at outpatient clinic at either site
- Able to understand information given and happy to give consent
- Exclusion criteria for healthy volunteers:
- Age \< 18 or \>85 years
- Evidence of renal dysfunction: proteinuria, raised serum creatinine
- Evidence of diabetes mellitus, significant hypertension (defined above), glomerulonephritis or other known cause of renal disease.
- Inclusion criteria for patients with CKD of known cause:
- Age 18- 85 years
- Attend general renal clinic in Anuradhapura or Padavi-Sri Pura
- Evidence of renal dysfunction: proteinuria, raised serum creatinine
- Known cause renal disease proven by biopsy or strong association such as diabetes mellitus or chronic, severe hypertension.
- Able to understand information given and happy to give consent
- Exclusion criteria for patients with CKD of known cause:
- Age \< 18 or \>85 years
- CKD unknown origin
- Pregnant
- Subjects who are on dialysis
Exclusion
Key Trial Info
Start Date :
September 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 1 2017
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT02226055
Start Date
September 1 2014
End Date
May 1 2017
Last Update
November 1 2017
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Teaching Hospital Anuradhapura
Anuradhapura, North Central Province, Sri Lanka, A13