Status:
UNKNOWN
FOLFOX6 as Neoadjuvant Chemotherapy in Local Advanced Gastric Cancer
Lead Sponsor:
Peking Union Medical College Hospital
Conditions:
Gastric Cancer
Effects of Chemotherapy
Eligibility:
All Genders
18-75 years
Phase:
PHASE2
Brief Summary
Purpose: This aim of the study is to evaluate the efficacy and safety of neoadjuvant chemotherapy with the modified FOLFOX6(mFOLFOX6) regimen and its impact on survival on a series in local advanced g...
Eligibility Criteria
Inclusion
- Eligibility criteria included histologically confirmed gastric cancer, the gastro-oesophageal junction(GEJ) may be involved, but the bulk of the tumour has to be in the stomach; age ≥18 years old, ECOG performance status score ≤2, no prior chemotherapy, TNM stage of T2-T4 or positive regional lymph nodes by endoscopic ultrasound or computed tomography (CT), and adequate hematological, heart, liver and renal functions (ALT and AST≤2.5 UNL, total bilirubin ≤1.5 UNL, and serum creatinine ≤1.5 UNL).
Exclusion
- Patients with second malignancies or evidence of severe or uncontrolled systemic disease were excluded.
Key Trial Info
Start Date :
October 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
75 Patients enrolled
Trial Details
Trial ID
NCT02226380
Start Date
October 1 2013
Last Update
August 27 2014
Active Locations (2)
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1
Department of Oncology and Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences
Beijing, Beijing Municipality, China, 100032
2
Peking Union Medical College Hospital
Beijing, Beijing Municipality, China, 100032