Status:
COMPLETED
The Effect of a Selective Serotonin Reuptake Inhibitor on Gait, Balance, and Bone Metabolism in Older Adults
Lead Sponsor:
University Health Network, Toronto
Conditions:
Depression
Eligibility:
All Genders
65+ years
Phase:
PHASE4
Brief Summary
The purpose of this study is to examine the effects of sertraline treatment of depression in older adults on gait stability, balance recovery reactions, and markers of bone metabolism. This is a pilot...
Detailed Description
Selective serotonin reuptake inhibitors (SSRIs) are a class of antidepressant medication frequently used to treat depressive and anxiety disorders in the elderly. Although widely considered to be a sa...
Eligibility Criteria
Inclusion
- Depressed group
- Clinical diagnosis of Major Depression
- English-speaking
- If currently on an antidepressant, willing to undergo a 2 week washout.
Exclusion
- Lifetime bipolar disorder
- Current psychotic disorder or substance use disorder
- Dementia
- Poor baseline mobility or baseline severe gait disorder
- On treatment with fluoxetine or mood stabilizer
- Severe renal impairment, bleeding disorder, recent gastric bleeding or hemorrhagic stroke in past 3 months
- Poor response or serious adverse event with sertraline in the past.
- Comparison group
- Inclusion Criteria:
- \- English-speaking
Key Trial Info
Start Date :
July 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2016
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT02228005
Start Date
July 1 2014
End Date
July 1 2016
Last Update
May 4 2017
Active Locations (1)
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1
Toronto Rehabilitation Institute, University Health Network
Toronto, Ontario, Canada, M5G2A2