Status:
COMPLETED
A Family Study of Copy Number Variations in Patients With Autism Spectrum Disorder
Lead Sponsor:
National Taiwan University Hospital
Conditions:
Autism Spectrum Disorder
Eligibility:
All Genders
3+ years
Brief Summary
This 3-year proposal is a family-based cohort study to establish a representative sample of probands with ASD and their parents with well-characterized environmental, clinical phenotypes, endophenotyp...
Detailed Description
Due to its high prevalence, long-term impairment, high genetic component (heritability \> 90%), and lack of effective prevention and treatment, ASD has been prioritized for genetic studies. However, d...
Eligibility Criteria
Inclusion
- subjects have a clinical diagnosis of autistic disorder or Asperger disorder defined by the DSM-IV and ICD-10 criteria and ASD defined by the DSM-5, which was made by board-certificated child psychiatrists at the first visit and following visits;
- their ages range from 3 to 30;
- subjects have at least one biological parent;
- both parents are Han Chinese; and
- subjects and their biological parents consent to participate in this study for complete phenotype assessments and blood withdraw for genetic study.
Exclusion
- if they currently meet criteria or have a history of the following condition as defined by DSM-IV: Schizophrenia, Schizoaffective Disorder, or Organic Psychosis.
Key Trial Info
Start Date :
August 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 31 2017
Estimated Enrollment :
360 Patients enrolled
Trial Details
Trial ID
NCT02228876
Start Date
August 1 2014
End Date
July 31 2017
Last Update
September 5 2021
Active Locations (1)
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1
National Taiwan Univeristy Hospital
Taipei, Taiwan