Status:
COMPLETED
Sodium Fluoride Imaging of Abdominal Aortic Aneurysms
Lead Sponsor:
University of Edinburgh
Collaborating Sponsors:
Chief Scientist Office of the Scottish Government
Conditions:
Abdominal Aortic Aneurysm
Eligibility:
All Genders
50+ years
Brief Summary
The purpose of this study is to determine whether Sodium Fluoride imaging (using Positron Emission Tomography-Computed Tomography - PET-CT) is able to help predict the rate of abdominal aortic aneurys...
Detailed Description
Ruptured abdominal aortic aneurysms (AAAs) have a 90% mortality rate but there are currently no accurate methods of establishing the risk of rupture for an individual patient with an asymptomatic AAA....
Eligibility Criteria
Inclusion
- Inclusion Criteria (AAA patients):
- Patients already enrolled in the MA3RS study (ISRCTN76413758)
- Patients with abdominal aortic aneurysm with AP diameter \>40 mm on ultrasound
- \>50 years of age
- Inclusion Criteria (control patients):
- Patients with abdominal aorta with AP diameter \<30 mm on ultrasound
- \>50 years of age
- Exclusion Criteria:
- Patients expected to undergo imminent AAA repair
- Patients who refuse or are unable to give informed consent
- Women of child-bearing potential without contraception
- Patients who are unable to undergo PET-CT scan
- Patients with collagen vascular disease
- Intercurrent illness, malignancy or comorbidity with life expectancy \<1 year
- Renal dysfunction (eGFR \<30ml/min/1.73m2)
- Contraindication to PET-CT or CTA
- Iodine allergy
Exclusion
Key Trial Info
Start Date :
September 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 1 2017
Estimated Enrollment :
96 Patients enrolled
Trial Details
Trial ID
NCT02229006
Start Date
September 1 2014
End Date
February 1 2017
Last Update
May 17 2017
Active Locations (1)
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1
Royal Infirmary of Edinburgh
Edinburgh, United Kingdom, EH16 4SA