Status:
COMPLETED
The Relationship Between Sleep and Glucose Tolerance in Prediabetes: the Role of GLP-1 in Short Sleepers
Lead Sponsor:
Ramathibodi Hospital
Collaborating Sponsors:
Merck Sharp & Dohme LLC
Conditions:
Prediabetes
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Hypothesis 1. Prediabetes patients who have insufficient sleep will have worse glucose tolerance than those with normal sleep duration. 2. Prediabetes patients with short sleep will have a delayed or...
Eligibility Criteria
Inclusion
- Patients with prediabetes (HbA1c 5.7-6.4% or history of fasting plasma glucose 100-125 mg/dl) who receive medical care at Ramathibodi Hospital
- Age 18 or older
- Can understand Thai (speaking, listening and reading)
- Agree to participate by written informed consent
Exclusion
- Those who depend on others for feeding (such as stroke patients)
- Shift workers
- History of congestive heart failure or low ejection fraction
- Chronic obstructive pulmonary disease, end stage renal disease or chronic liver disease (AST or ALT \> 3 times the upper limit of normal)
- Use of medications: opioids/ narcotics , alpha blockers (prazosin, doxazosin, terazosin), clonidine, methyldopa, nitroglycerin
- Patients with permanent pacemaker
- History of previous stroke
Key Trial Info
Start Date :
October 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 31 2017
Estimated Enrollment :
51 Patients enrolled
Trial Details
Trial ID
NCT02229487
Start Date
October 1 2014
End Date
March 31 2017
Last Update
October 10 2017
Active Locations (1)
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1
Faculty of Medicine Ramathibodi Hospital
Bangkok, Thailand