Status:
COMPLETED
Fairly Brief Androgen Suppression and Stereotactic Radiotherapy for High Risk Prostate Cancer - Protocol 2
Lead Sponsor:
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Conditions:
Prostate Cancer
Eligibility:
MALE
70+ years
Phase:
PHASE2
Brief Summary
This study will explore the combination of a stereotactic body radiation therapy (SBRT) approach combined with one year of luteinizing hormone releasing hormone (LHRH) agonist for older men with high ...
Detailed Description
Randomized controlled trials have established the improved efficacy (better biochemical control and disease free survival) of combined radical radiation (70-80 Gy over 7-8 weeks) combined with long te...
Eligibility Criteria
Inclusion
- High risk prostate cancer
- Has had multidisciplinary consultation with radiation oncologist and urologist
- Age \>70 or refuses standard treatment
- No evidence of extra-prostatic disease on screening bone scan and CT scan (non-contrast CT used for CT simulation acceptable)
- Signed written and voluntary informed consent provided.
- Patients must be willing and able to comply with scheduled visits, treatment plan, laboratory tests, and other study procedures
Exclusion
- Patients not meeting the eligibility criteria
- Prior pelvic radiotherapy or brachytherapy
- Use of anti-coagulation (low molecular weight heparin or Coumadin)
- History of inflammatory bowel disease, Crohn's disease, diverticulitis or collagen vascular disease (other than rheumatoid arthritis)
- Previous treatment for malignancy (other than basal or squamous cell skin cancer) within 3 years of prostate cancer diagnosis
- patients on androgen deprivation therapy \> 2 months prior to study enrolment
Key Trial Info
Start Date :
December 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2021
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT02229734
Start Date
December 1 2014
End Date
June 1 2021
Last Update
June 4 2021
Active Locations (1)
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1
London Regional Cancer Program of the Lawson Health Research Institute
London, Ontario, Canada, N6A 4L6