Status:
COMPLETED
Endothelial Microparticles: A Novel Marker of Vascular Dysfunction
Lead Sponsor:
University of Colorado, Denver
Conditions:
Chronic Kidney Disease
Eligibility:
All Genders
18-100 years
Brief Summary
The primary hypothesis of this proposal is that chronic kidney disease (CKD) and treatment with calcineurin inhibitors (CNIs) are each associated with the release of endothelial microparticles into th...
Detailed Description
The primary hypothesis of this proposal is that chronic kidney disease (CKD) and treatment with calcineurin inhibitors (CNIs) are each associated with the release of endothelial microparticles into th...
Eligibility Criteria
Inclusion
- For Healthy controls:
- BMI less than 40 kg/m\^2
- Able to give informed consent
- For Stage III or IV CKD patients:
- BMI less than 40 kg/m\^2
- Able to give informed consent
- An estimated Glomerular-Filtration Rate (GFR) of 20-60 mL/min/1.73m\^2
- For Post-kidney transplant and stage III or IV CKD patients:
- BMI less than 40 kg/m\^2
- Able to give informed consent
- An estimated Glomerular-Filtration Rate (GFR) of 20-60 mL/min/1.73m\^2
Exclusion
- For Healthy controls:
- Women pregnant or breastfeeding
- For Stage III or IV CKD patients:
- Women pregnant or breastfeeding
- Adults with a life expectancy of less than one year
- A history of significant liver disease or congestive heart failure
- Hospitalization within the last three months
- Active infection on antibiotic therapy
- Uncontrolled hypertension (\>140/90)
- Immunosuppressive therapy within the last year
- For Post-transplant stage III or IV CKD patients:
- Women pregnant or breastfeeding
- Adults with a life expectancy of less than one year
- A history of significant liver disease or congestive heart failure
- Hospitalization within the last three months
- Active infection on antibiotic therapy
- Uncontrolled hypertension (\>140/90)
Key Trial Info
Start Date :
September 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 1 2016
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT02230202
Start Date
September 1 2014
End Date
March 1 2016
Last Update
February 28 2018
Active Locations (2)
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1
University of Colorado Anschutz Medical Campus; CTRC
Aurora, Colorado, United States, 80045
2
University of Colorado School of Medicine
Aurora, Colorado, United States, 80045