Status:
COMPLETED
Identifying Expression Markers of Cumulus Cells to Identify Oocyte Developmental Potential Through a Maturation Analysis
Lead Sponsor:
Memorial Sisli Hospital, Istanbul
Conditions:
Infertility
Eligibility:
FEMALE
18-39 years
Brief Summary
The aim of the study is to analyze the expression of genes and microRNAs potentially involved in oocyte competence in follicles of different sizes (\<17mm and ≥17mm) at the time of oocyte pick-up.
Detailed Description
In ART, one of the major obstacles encountered in some patients is the wide variation in the follicular size at the oocyte pick-up day and consequently, the number of available mature oocytes and the ...
Eligibility Criteria
Inclusion
- No more than 2 previous treatment cycles
- No history of recurrent spontaneous abortions
- Age ≤ 39 years
- BMI \< 30 kg / m2
- ≥ 8 cumulus-oocyte-complexes (COC) retrieved
- human Chorionic Gonadotrophin (hCG) triggering
Exclusion
- Preimplantaion Genetic Diagnosis (PGD) or Preimplantation Genetics Screening (PGS) indication
- Maximum number of 24 COC during pickup
- Failure to culture until Day 5
- Polycystic ovary syndrome
- Severe endometrial factor that can influence implantation
- Uterine malformation or congenital anomaly
- Severe male factor (Azoospermia)
Key Trial Info
Start Date :
August 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 1 2016
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT02230449
Start Date
August 1 2014
End Date
September 1 2016
Last Update
September 5 2017
Active Locations (1)
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1
Memorial Sisli Hospital ART Center
Istanbul, Turkey (Türkiye), 34385