Status:
COMPLETED
PET Imaging of Brain mGluR1 Receptors Using [18F]FIMX
Lead Sponsor:
National Institute of Mental Health (NIMH)
Conditions:
Anxiety Disorder
Major Depressive Disorder
Eligibility:
All Genders
18-55 years
Brief Summary
Objective: Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors that respond to glutamate by activating proteins inside nerve cells that affect cell metabolism, thereby fine-tuni...
Detailed Description
Objective: Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors that respond to glutamate by activating proteins inside nerve cells that affect cell metabolism, thereby fine-tuni...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Age 18 to 55.
- Able to give written informed consent.
- EXCLUSION CRITERIA:
- Any current Axis I diagnosis.
- Clinically significant laboratory abnormalities.
- Positive HIV test.
- Unable to have an MRI scan.
- History of neurologic illness or injury with the potential to affect study data interpretation.
- Recent exposure to radiation (i.e. PET from other research) that, when combined with this study, would be above the allowable limits.
- Inability to lie flat on camera bed for at least two hours.
- Pregnancy or breast feeding.
- Able to get pregnant but does not use birth control.
- History of drug or alcohol abuse within 6 months or a history of alcohol or drug dependence (excepting nicotine) within 3 years
- Exclusion criteria for the dosimetry subjects are the same as reported above, with the exception of MRI contraindications, because an MRI will not be performed in these subjects.
Exclusion
Key Trial Info
Start Date :
November 8 2013
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 16 2016
Estimated Enrollment :
19 Patients enrolled
Trial Details
Trial ID
NCT02230592
Start Date
November 8 2013
End Date
June 16 2016
Last Update
July 5 2018
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892