Status:
COMPLETED
A Study of IDN-6556 in Subjects With Liver Cirrhosis
Lead Sponsor:
Conatus Pharmaceuticals Inc.
Conditions:
Liver Cirrhosis
Hepatic Cirrhosis
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
This is a multicenter study to see if treatment with IDN-6556 can help improve the liver function of patients with liver cirrhosis with Model for End-Stage Liver Disease scores between 11-18.
Detailed Description
Numerous studies have shown that caspase cleaved cytokeratin 18 (cCK18) is elevated in the serum of liver disease patients and has been associated with disease severity, thus associating both excessiv...
Eligibility Criteria
Inclusion
- Male or female subjects of minimum adult legal age (according to local laws for signing the informed consent document), able to provide written informed consent, and able to understand and willing to comply with the requirements of the study
- Clinical, radiological, or biochemical evidence of liver cirrhosis
- Model for End-Stage Liver Disease (MELD) Score of 11 to 18 during the Screening period
- Willingness to utilize two reliable forms of contraception (for both males and females of childbearing potential) from Screening to one month after the last dose of study drug.
Exclusion
- Known infection with human immunodeficiency virus (HIV)
- Auto-immune hepatitis
- Subjects with evidence of uncontrolled infection, defined as persistent bacterial culture positivity despite adequate antibiotic therapy
- HCV infected subjects who are receiving or plan to receive anti-viral therapy during the study
- Untreated esophageal varices with high risk stigmata for hemorrhage
- Variceal hemorrhage within 3 months of Screening
- Ascites not adequately controlled on stable background medication
- Other non-liver organ failure
- Child-Pugh score of 10-15 (Child-Pugh C classification)
- Use of vasoactive drugs (at or within 3 months of Screening) that may impair hepatic blood flow
- Change in dose or regimen within 3 months of Screening of:
- Fibrates or statins
- Angiotensin II receptor antagonist or angiotensin converting enzyme (ACE) inhibitor
- Use of chronic anticoagulation therapy including but not limited to Vitamin K/Factor Xa antagonists/inhibitors
- Use of the following drugs within 2 months of Screening:
- Systemic corticosteroids
- Known or suspected use of illicit drugs or drugs of abuse (allowed if medically prescribed or indicated)
- Concomitant pancreatitis
- Active inflammatory bowel disease
- Diagnosed or suspected systemic lupus erythematosus (SLE) and/or rheumatoid arthritis (RA)
- Subjects with active or history of malignancies other than hepatocellular carcinoma (HCC) within Milan criteria or curatively treated skin cancer (basal cell or squamous cell carcinomas), unless adequately treated or in complete remission for five or more years
Key Trial Info
Start Date :
August 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2016
Estimated Enrollment :
87 Patients enrolled
Trial Details
Trial ID
NCT02230670
Start Date
August 1 2014
End Date
January 1 2016
Last Update
July 5 2017
Active Locations (28)
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1
University of Alabama at Birmingham
Birmingham, Alabama, United States, 35233
2
Scripps Clinic
La Jolla, California, United States, 92037
3
Loma Linda University Medical Center
Loma Linda, California, United States, 92354
4
Cedar-Sinai Medical Center
Los Angeles, California, United States, 90048